[5], Discoid lupus erythematosus (DLE) skin lesions first present as dull or purplish red, disc-shaped flat or raised and firm areas of skin. [3][5], In order to help with diagnosis, the doctor may peel off the top layer of scale from a patient's lesions in order to look at its underside. von griechisch: δίσκος ("diskos") - Scheibe Im oberen Korium sieht man als Zeichen der Immunreaktion ein perivasales Infiltrat aus Lymphozyten sowie einen Abbau der Kollagenfasern und elastischen Fasern. Es können auch andere Körperregionen betroffen sein, wie das Dekolleté oder die Streckseiten der Extremitäten. James, William; Berger, Timothy; Elston, Dirk (2005). [4], Of note, patients with systemic lupus erythematous develop discoid lupus lesions with some frequency. Lebensjahr ihren Gipfel. [3], Some experts consider hypertrophic lupus erythematosus—which consists of lesions covered by a very thick, keratin-filled scale—an unusual subset of discoid lupus. How to say discoid lupus erythematosus in English? These l… [3], When discoid lupus is on the scalp, it starts as a red flat or raised area of skin that then loses hair and develops extensive scarring. References ; Prognosis. [4] Others consider it a distinct entity. Lupus is a systemic autoimmune disease that occurs when your body's immune system attacks your own tissues and organs. [3], When patients develop discoid lupus in childhood, it differs from typical discoid lupus in several ways. Discoid lupus (discoid lupus erythematosus) is a chronic autoimmune disease affecting the skin. Chronische Form des kutanen Lupus erythematodes, die bevorzugt die Gesichtshaut befällt. Es handelt sich um die häufigste Form des kutanen Lupus erythematodes. [3][5] These lesions then develop increasing amounts of white, adherent scale. [3], Sun exposure triggers lesions in people with discoid lupus erythematous (DLE). [3] They also often have auto-antibodies, such as ANA or anti-ssDNA antibody. [5] In addition, these patients have an increased, though still small, risk for aggressive skin squamous cell carcinoma. [3] The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. Die Prognose des diskoiden Lupus erythematodes ist - mit Ausnahme der Beeinträchtigung der Hautästhetik - insgesamt gut. Discoid Lupus Erythematosus Definition Discoid lupus erythematosus (DLE) is a disease in which coin-shaped (discoid) red bumps appear on the skin. Die Angaben schwanken jedoch, da in älteren Studien meist nicht zwischen den verschiedenen LE-Formen differenziert wurde. ultraviolette Strahlung), irritativen Stimuli und Medikamenten, spielen genetische Faktoren eine Rolle. We therefore conducted an open study in patients with discoid lupus erythematosus treated with sulfasalazine. Introduction: Antimalaria agents and thalidomide are two reference drugs for discoid lupus erythematosus. Auf unbefallener Haut ist der Test negativ. [13][14], Cutaneous keratosis, ulcer, atrophy, and necrobiosis, Systemic lupus erythematosus with discoid lupus lesions. Die entzündlichen Veränderungen betreffen in erster Linie die Haut. Cutaneous lupus erythematosus, or CLE, refers to forms of lupus that affect the skin, causing rashes and sores. [3][5] This finding is 90% sensitive; however, false positives can occur with biopsies of facial lesions. [3], If a patient has discoid lupus lesions on top of lupus panniculitis, they have lupus profundus. The most common types are acute cutaneous lupus (ACLE), subacute cutaneous lupus (SCLE), and discoid lupus (DLE). The face (bridge of the nose, cheeks, lower lip, the ears, or inside the mouth) and/or the scalp are most often affected. Discoid lupus on the other hand, usually causes a much more pronounced, and sometimes scarring, rash on the face and may also result in severe hair loss and scarring of the scalp. Discoid lupus erythematosus most commonly afflicts young adult females, especially individuals of African and Hispanic descent, though it may occur at any age and it occurs worldwide. [3] If the patients does indeed have discoid lupus, the doctor may see tiny spines of keratin that look like carpet tacks and are called langue au chat. [3] On lighter skin, the lesions often develop a gray color or have very little color change. [5] However, 25% of patients with SLE get discoid lupus lesions at some point as part of their disease. [3][5] The epidermis appears thin and has effaced rete ridges as well as excess amounts of keratin clogging the openings of the follicles. Es bilden sich dabei unterschiedlich große, scharf begrenzte, schuppende, infiltrierte Erytheme, die dazu neigen mit Atrophie, Narbenbildung und Pigmentverschiebungen abzuheilen. Bei Afrikanern kommt die Erkrankung häufiger vor. Of all the people who have DLE, about 10 percent will develop the more serious SLE. Bei einem kleinen Teil der Patienten (< 5%) kann der kutane Lupus in einen systemischen Lupus erythematodes (SLE) übergehen. This condition causes a … Discoid lupus erythematosus mainly affects skin that is exposed to sunlight and doesn’t typically affect vital internal organs. Die Inzidenz der Erkrankung nimmt mit dem Alter zu und erreicht zwischen dem 60. und 69. [4], Treatment for discoid lupus erythematosus includes smoking cessation and a sunscreen that protects against both UVA and UVB light as well as very strong topical steroids or steroids injected into the lesions. Sie können kreisförmig, oval oder unregelmäßig girlandenförmig konturiert sein und sich zentripetal ausbreiten. The exact reason of discoid lupus erythematosus is still not known, but the suspected cause implicates towards autoimmune disorder, which is usually responsible for forcing the immune system of the body to attack its own healthy … Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study. discoid lupus erythematosus causes. Discoid Lupus Erythematosus (DLE) in Dogs. These lesion… Boys and girls are equally affected, and these patients later develop SLE more often. [5] In addition, pathologists often see groups of white blood cells, particularly T helper cells, around the follicles and blood vessels in the dermis. Dry Eye (Keratoconjunctivitis Sicca) in Dogs and Cats . Synonyme: chronisch diskoider Lupus erythematodes, CDLE, Lupus erythematodes chronicus discoides [5] This material diffuses to the dermoepidermal junction, where it binds to circulating antibodies, thereby leading to a series of inflammatory reactions by the immune system. Retinoide, Thalidomid, Tacrolimus sowie Immunsuppressiva wie Azathioprin oder Ciclosporin in Frage. [5], Alternatively, dysfunctional T cells may lead to the disease. Discoid lupus erythematosus (DLE) is the most common form of chronic CLE and may be the initial presentation of SLE in up to 10% of cases (2). [5] Typical biopsy findings include deposits of IgG and IgM antibodies at the dermoepidermal junction on direct immunofluorescence. Die Prävalenz des systemischen Lupus erythematodes ist stark abhängig von der ethnischen Zugehörigkeit. Die Flecken treten vor allem im Gesicht und auf der Kopfhaut auf. Frauen sollen nach manchen Quellen etwa 3x häufiger betroffen sein als Männer, nach anderen Quellen etwa gleich häufig. [3], In general, patients with discoid lupus who have only skin disease and no systemic symptoms have a genetically distinct disease from patients with SLE. [5] Patients are first treated with sunscreen and topical steroids. [3], The differential diagnosis includes actinic keratoses, sebborheic dermatitis, lupus vulgaris, sarcoidosis, drug rash, Bowen’s disease, lichen planus, tertiary syphilis, polymorphous light eruption, lymphocytic infiltration, psoriasis, and systemic lupus erythematosus. Dust Mites: Minimizing Exposure in Dogs and Cats. [8] For oral treatment, hydroxychloroquine and acitretin are equally effective; however, acitretin was associated with more adverse effects. Discoid lupus is the most common type of CLE. [5] Other oral medications used to treat discoid lupus include retinoids (isotretinoin or acitretin), dapsone, thalidomide (teratogenic, side effects include peripheral neuropathy), azathioprine, methotrexate, or gold. Discoid lupus erythematosus (DLE) is a rare disorder in childhood, with 22 cases reported in the English-language literature. Cutaneous lupus erythematosus (CLE) can be divided into three main subtypes: acute, subacute, and chronic, all of which demonstrate photosensitivity. Hair loss may occur if the lesions are on the scalp. In Europa liegt sie zwischen 25 und 40 Fällen auf 100.000 Einwohner, in Asien beträgt sie rund 50 Fälle pro 100.000 Einwohner. DLE usually presents in people aged between 20 and 40 years of age. Hautkrankheit, Der diskoide Lupus erythematodes (DLE) ist eine Autoimmunerkrankung der Haut, die sich in Form von roten, klar abgegrenzten, schuppenden Bereichen zeigt. [5], Possibly, UV light damages skin cells, which then release material from their nuclei. Die Herde sind randbetont. 2020 Jan. 45 (1):89 … [5], Most experts consider DLE an autoimmune disease since pathologists see antibodies when they biopsy the lesions and look at the tissue under the microscope. Hyperpigmentierungen und Teleangiektasien kommen ebenfalls vor. Der Befund hinterlässt in einem manchmal über Jahre laufenden Abheilungprozess eine reizlose, in das Hautniveau eingesunkene Narbe. Discoid lupus erythematosus (DLE) is a form of lupus that mainly affects your skin. reibender Hemdkragen) können Erkrankungsherde hervorrufen, was man als Köbner-Phänomen bezeichnet. an Zehen und Fingern auftreten. PubMed Google Scholar 8. If you have discoid lupus, you may develop chronic inflammatory sores on your face, ears, scalp, and other areas of the body. Selten kommt es zu einer überschießenden Verhornung, die Oberfläche kann dann einen warzenartigen Charakter annehmen, was als Lupus erythematosus verrucosus adressiert wird. [3][5], Discoid lupus can be broadly classified into localized discoid lupus and generalized discoid lupus based on the location of the lesions. Skin lesions of DLE are mainly localized in sun-exposed areas and may lead to scarring and disfigurement. [3], The musician Seal has this skin condition. [4] These patients have firm, nontender nodules with defined borders underneath their discoid lupus lesions. Lupus erythematosus is a multisystem disorder that predominately affects the skin. [11], Singer Michael Jackson was reportedly diagnosed with discoid lupus in 1984; the condition might have damaged his nasal cartilage and led to some of his cosmetic surgery. Die Effloreszenzen weisen bei der klinischen Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit (Hypersensitivität) auf. Hautreizungen (z.B. Es gibt aber auch Verlaufsformen, bei denen noch andere Organe mitbeteiligt sind. In der Regel … Signs and Symptoms. [3], Rarely, patients may have lesions above and below the neck; these patients have generalized discoid lupus erythematosus. [3], The lesions are diagnosed by biopsy. There are several types of cutaneous lupus. Discoid lupus is an autoimmune disease where the immune system attacks the skin. Um diesen Artikel zu kommentieren, melde Dich bitte an. [3], Hypertrophic lupus and lupus profundus are two special types of discoid lupus distinguished by their characteristic morphological findings. These patients rarely present with significant organ involvement and generally have a good prognosis (3,4). cutis = Haut) (CLE), auch Lupus erythematodes cutaneus oder Hautlupus, ist meistens nur die Haut betroffen. Im Stratum basale kommt es zu einer Degeneration der Stammzellen mit zahlreichen Einzelzellnekrosen, die sich als eosinophile Zellrest… [4][5] 50% of patients will eventually get better on their own. Copyright ©2021 DocCheck Medical Services GmbH |, Lupus: Vom Virus zum Schmetterling (DocCheck News), Was COVID-19 und Lupus gemeinsam haben (Corona auf einen Blick), Autoimmunität: Warum Lupus weiblich ist (DocCheck News), Gleicher Pathomechanismen bei COVID-19 und Lupus? [3][5] In addition to their skin lesions, they may also have swelling and redness around their eyes, as well as blepharitis. Pathohistologisch zeigt sich eine Atrophie der Epidermis mit Orthohyperkeratose und follikulärer Keratose. Englisch: discoid lupus erythematosus. Als Variante ist der hypertrophe chronisch diskoide Lupus erythematodes ( Lupus erythematodes verrucosus) anzusehen. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. However, it can also present as a diffuse morbilliform eruption with erythema and edem… Discoid lupus erythematosus as part of a larger disease spectrum. [9] For patients with scalp disease, hair transplantation can help with their hair loss. Discoid lupus erythematosus (DLE) is responsible for 50-85% of cases of CLE and occurs 2-3 times more frequently in women than in men. The exact cause of DLE is unknown, but it is described as an autoimmune disease where the discoid lupus symptoms present as a rash and … Pathohistologisch zeigt sich eine Atrophie der Epidermis mit Orthohyperkeratose und follikulärer Keratose. Der Prozess der narbigen Ausheilung kann sich über Jahre hinwegziehen. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. Neben Umweltfaktoren (z.B. Die Erkrankung kann nach Jahren oder Jahrzehnten von selbst zum Stillstand kommen. Although DLE may occur at any age, it most often develops in persons aged 20-40 years. List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer, "Cutaneous Lupus Erythematosus | American Skin Association", "Ocular Complications in Cutaneous Lupus Erythematosus: A Systematic Review with a Meta-Analysis of Reported Cases", "Journal of the American Academy of Dermatology", "A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia", "At Lunch With: Seal; From a Crucible Of Early Pain Comes the Gold Of Stardom", Opinion:To understand Michael Jackson and his skin, you have to go beyond race, "Cutaneous lupus erythematosus in dogs: a comprehensive review", Seborrheic keratosis with squamous atypia, Palisaded neutrophilic and granulomatous dermatitis, Lupus erythematosus–lichen planus overlap syndrome, Morphea–lichen sclerosus et atrophicus overlap, https://en.wikipedia.org/w/index.php?title=Discoid_lupus_erythematosus&oldid=1000946900, Creative Commons Attribution-ShareAlike License, Discoid lupus erythematosus lesion on the face of musician, This page was last edited on 17 January 2021, at 14:08. [2][7] If this does not help the patient, his or her physician can prescribe an antimalarial medication such as oral hydroxychloroquine or chloroquine. Der diskoide Lupus erythematodes, kurz DLE, ist ein Subtyp des kutanen Lupus erythematodes (CLE). 1975 Nov. 111(11):1448-52. . Hashimoto K, Thompson DF. These lesions develop as a red, inflamed patch with a scaling and crusty appearance. [12], Dogs and horses can also get discoid lupus. Lupus sometimes runs in families. Lupus erythematodes verläuft in der Regel schubförmig. Lupus erythematodes. Seine jährliche Inzidenz liegt bei etwa 5-10 Fällen pro 100.000 Einwohner. It … Discoid lupus erythematosus (DLE) is a chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas. [5], When a patient initially presents with discoid lupus, the doctor should ensure that the patient does not have systemic lupus erythematosus. [5] The remains of skin cells that have died through a process called apoptosis are visible in the upper layer of the dermis and the basal layer of the epidermis. [1] Dezember 2018 um 14:40 Uhr bearbeitet. Electron microscopic studies of paramyxovirus-like structures. Inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart and lungs.Lupus can be difficult to diagnose because its signs and symptoms often mimic those of other ailments. Hair loss may occur if the lesions are on the scalp. The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. 2017;77:261–7. [3], Patients may state that their lesions are itchy, tender, or asymptomatic. Samotij D, Szczech J, Kushner CJ, Mowla MR, Danczak-Pazdrowska A, Antiga E, et al. Dr. James Gilliam described the most commonly used classification of cutaneous lesions in lupus erythematosus. Clin Exp Dermatol. Aus allen Formen des kutanen Lupus erythematodes (CLE) kann sich ein systemischer Lupus erythematodes (SLE) entwickeln. dermis.net:80. dermis.net:80. Systemic lupus, which is so called because it affects internal organs, generally produces a mild rash or flush on the face. Neben Umweltfaktoren (z.B. Schlägt die Standardtherapie nicht an, kommen u.a. [3][5], More rarely, patients may have lesions on the head and neck as well as the arms and trunk. It gets its name from the coin-shaped lesions it produces. [8], Pulsed dye laser is also an effective treatment for patients with localized discoid lupus. Distichiasis Requires Permanent Eyelash Removal in Dogs. Er ist durch blaurote, berührungsempfindliche, frostbeulenartige Knoten gekennzeichnet, die v.a. [5][6] The disease tends to affect young adults, and women are affected more than men in a 2:1 ratio. 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Good prognosis ( 3,4 ), refers to forms of lupus panniculitis, They have profundus..., false positives can occur with biopsies of facial lesions lupus only lesions!, ist meistens nur die Haut, Possibly, UV light damages skin,. Effloreszenzen weisen bei der klinischen Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit ( Hypersensitivität auf! Zu kommentieren, melde Dich bitte an slightly more common in African than! Oral medication—most likely hydroxychloroquine or a related medication—can be tried ( CLE ) kann sich ein lupus... Also be used people aged between 20 and 40 years of age a scaling crusty. Or Asians erythematosus is a chronic condition, and these patients later SLE! And these patients have generalized discoid lupus erythematosus sich eine Atrophie der Epidermis mit Orthohyperkeratose und follikulärer Keratose in Entzündungszone! Auto-Antibodies, such as ANA or anti-ssDNA antibody Intravascular Coagulation ( DIC ) in Dogs and Cats equally effective However... Affects skin that is exposed to sunlight and doesn ’ t typically affect vital internal organs these antibodies the. Lupus that affect the skin kleinen Teil der Patienten ( < 5 % ) kann sich ein systemischer lupus (. Sich darüber hinaus eine bleibende Alopezie, Dogs and Cats, dilated hair on... Bei etwa 5-10 Fällen pro 100.000 Einwohner whites or Asians of white, adherent scale Inzidenz...

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